Dr. Manasi Mishra is working as Associate Professor in School of Biology, MIT-World Peace University. She received her Ph.D in Biotechnology from CSIR-National Chemical Laboratory, Pune. She is also a recipient of short-term DAAD fellowship and conducted collaborative research at EMBL Hamburg, Germany. After completing her doctoral research, she worked at the Institute of Organic Chemistry and Bio-Chemistry, Academy of Sciences of the Czech Republic, Prague. She is also the recipient of DST-INSPIRE Faculty Fellowship award from Department of Science & Technology and Indo-Australian Career Boostting Gold Fellowships from Department of Biotechnology. She has been actively working in the area of plant immunity proteins and peptides involved in defense against insect pest infestation and those with relevance in the context of crop improvement. Her research has been focused on structure-function correlation of diverse plant defense proteins, molecular diversity and their functional significance. She is also actively working in the areas of protein/peptide engineering for therapeutic applications
B.Sc. (H) Botany
Selected Research Publications:
Mishra M, Tamhane VA, Khandelwal N, Kulkarni MJ, Gupta VS and Giri AP (2010) Interaction of recombinant CanPIs with Helicoverpa armigera gut proteases reveals their processing patterns, stability and efficiency. Proteomics 10(15):2845-2857.
Mishra M, Singh V, Singh S (2019) Structural insights in to key Plasmodium proteases as therapeutic drug targets. Frontiers in Microbiology 10:394.
Mishra M#, Singh V#, Tellis MB, Joshi RS, Pandey KC, Singh S (2020) Cyclic peptide engineered from phytocystatin inhibitory hairpin loop as an effective modulator of falcipains and potent anti-malarial. Journal of Biomolecular Structure and Dynamics (https://doi.org/10.1080/07391102.2020.1848629).
Mishra M*, Singh V, Tellis MB, Joshi RS, Singh S* (2021) Repurposing the McoTI-II rigid molecular scaffold in to inhibitor of ‘papain superfamily’ cysteine proteases. Pharmaceuticals 14, 7: 1-17.
Teaching Experience : 4 years
Reaserch Experience : 8 years
Book Chapter:Gurjar G, Mishra M, Kotkar H, Upasani M, Pradeep Kumar, Tamhane V, Kadoo N, Giri A and Gupta V (2011). Book Chapter: Major biotic stresses of chickpea and strategies for their control. Pests and Pathogens: Management Strategies. BS Publications, CRC Press ISBN: 978-0-415-66576-6.
1. Ashok P. Giri, Rakesh S. Joshi, Vaijayanti A Tamhane, Manasi Mishra, Vidya S. Gupta, Anirban Ghosh, Uddhavesh Sonavane, Rajendra Joshi "Effective management of Helicoverpa armigera involves cloning of inhibitory repeat domain 9 in Pichia pastoris in specific vector, feeding inhibitory repeat domain 9 proteins to Helicoverpa armigera and calculating specific growth parameters”.
Patent Number: WO2013102937-A2; IN201200035-I1; WO2013102937-A3
US patent: 9,357,777
Biology for engineers, Synthetic Biology and Biologics production; Biotechnology Laboratory-02